Technical Service Need help? Our team of experienced experts is here for you with full support.
AKA-53
Camptothecin
Cat. No.
AKA-53
CAS No.
7689-03-4
MF
C20H16N2O4
MW
348.352
Camptothecin, a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor.
Advanced Equipments & Extensive Production Expertise
Commercial Manufacturing
Stable Quality
Customization Supporting
Technical Service 
86-28-85159085 
info@aktin.com
Technical Data
Description
Storage and Shipping
References
Product Name
Camptothecin
CAS No.
7689-03-4
MF
C20H16N2O4
MW
348.352
Specification
98%
Research Area
Intermediate
Description
Camptothecin, a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor. Packing: 1kg/bag; 25kg/drum or as request Availability: In Stock
Documents
Certificate of Analysis (COA), API specification, Safety Data Sheet (SDS/MSDS), evidence of GMP compliance, Stability data / Stability summary, etc.
Storage and Shipping
Store in a cool & dry place, keep away from strong light and heat.
References
[1]. Luzzio MJ, et al. Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I. Journal of Medicinal Chemistry. 1995 Feb;38(3):395-401.
[2]. Bertozzi D, et al. The natural inhibitor of DNA topoisomerase I, camptothecin, modulates HIF-1α activity by changing miR expression patterns in human cancer cells. Molecular Cancer Therapeutics. 2014 Jan;13(1):239-248. PMID: 24252850
[3]. Huang Q, et al. Evolution in medicinal chemistry of E-ring-modified Camptothecin analogs as anticancer agents. European Journal of Medicinal Chemistry. 2013;63:746-757.
[4]. Tesauro C, et al. Topoisomerase I activity and sensitivity to camptothecin in breast cancer-derived cells: a comparative study. BMC Cancer. 2019 Nov 29;19(1):1158.
[5]. Schön M, et al. KINK-1, a novel small-molecule inhibitor of IKKbeta, and the susceptibility of melanoma cells to antitumoral treatment. Journal of the National Cancer Institute. 2008;100(12):862-875.
[2]. Bertozzi D, et al. The natural inhibitor of DNA topoisomerase I, camptothecin, modulates HIF-1α activity by changing miR expression patterns in human cancer cells. Molecular Cancer Therapeutics. 2014 Jan;13(1):239-248. PMID: 24252850
[3]. Huang Q, et al. Evolution in medicinal chemistry of E-ring-modified Camptothecin analogs as anticancer agents. European Journal of Medicinal Chemistry. 2013;63:746-757.
[4]. Tesauro C, et al. Topoisomerase I activity and sensitivity to camptothecin in breast cancer-derived cells: a comparative study. BMC Cancer. 2019 Nov 29;19(1):1158.
[5]. Schön M, et al. KINK-1, a novel small-molecule inhibitor of IKKbeta, and the susceptibility of melanoma cells to antitumoral treatment. Journal of the National Cancer Institute. 2008;100(12):862-875.
Disclaimer
This product is intended solely for scientific research or regulatory filing purposes. We do not provide products or services to individuals, please strictly comply with all applicable laws, regulations, and the committed use. Use for any other purpose is strictly prohibited.
Related Products
AKA-384
Tedizolid phosphate
CAS No.: 856867-55-5
MF:C17H16FN6O6P
AKA-383
Brivaracetam
CAS No.:357336-20-0
MF:C11H20N2O2
AKA-382
Cobimetinib Fumarate
CAS No.:1369665-02-0
MF:C46H46F6I2N6O8
AKA-379
Bempedoic acid
CAS No.:738606-46-7
MF:C19H36O5
AKA-378
Borofalan(10B)
CAS No.:80994-59-8
MF:C9H12BNO4
AKA-377
AkProva™ Metildigoxin
CAS No.:30685-43-9(acetone-free)
MF:C42H66O14.1/2C3H6O
AKA-376
AkProva™ beta-Acetyldigoxin
CAS No.:5355-48-6
MF:C43H66O15
AKA-375
Ak-NucleoVia™ Agrostemmoside E
CAS No.:2656438-29-6
MF:C84H128O45
AKA-374
Novobiocin sodium
CAS No.:1476-53-5
MF:C31H35N2NAO11
AKA-360
Travoprost
CAS No.:157283-68-6
MF:C26H35F3O6
* Some statements have not been evaluated by national authorities. * Some products are not intended to diagnose, treat, cure, or prevent any disease. * For literature supporting, please contact us directly.
